HIPEC – Hyperthermic Intraperitoneal Chemotherapy

HIPEC is primarily used in selected patients with peritoneal spread of disease, most commonly in advanced or recurrent ovarian cancer.

Dr. Nikolopoulos has been trained at the internationally renowned peritoneal cancer center in Basingstoke, United Kingdom—one of the leading centers in Europe for cytoreductive surgery and HIPEC.

During his training, he participated in a large number of complex cytoreductive procedures combined with HIPEC for conditions including:

• Peritoneal cancer
• Advanced ovarian cancer
• Pseudomyxoma peritonei
• Other malignancies with peritoneal dissemination

This experience was gained in a high-volume, highly specialized oncological environment, enabling the application of modern, evidence-based treatment approaches.

HIPEC is performed immediately after cytoreductive surgery. During the procedure, heated chemotherapy is circulated within the abdominal cavity, allowing direct contact with residual cancer cells.

The rationale behind this approach includes:

• Enhanced tissue penetration of chemotherapy due to heat
• Targeted treatment of microscopic residual disease
• Improved local disease control in selected cases

This is a complex procedure requiring a highly specialized surgical and oncological approach.

HIPEC is not suitable for all patients and is offered only after thorough evaluation. Proper patient selection is essential for achieving optimal outcomes.

Particular emphasis is placed on:

• Detailed preoperative assessment
• Individualized treatment planning
• Adherence to international guidelines

This structured approach ensures that HIPEC is applied only when there is a clear clinical benefit.

Each patient is evaluated individually, taking into account the extent of disease and overall health status. HIPEC is incorporated into a comprehensive treatment plan when appropriate.

Particular emphasis is placed on:

• Clear patient communication and counseling
• Balancing potential benefits and risks
• Optimizing perioperative care

HIPEC is a specialized therapeutic option for the management of advanced gynecologic cancers with peritoneal spread.

With training at an internationally recognized center and experience in complex cytoreductive procedures combined with HIPEC, Dr. Nikolopoulos applies modern, evidence-based treatment strategies focused on safety, effectiveness, and improving the patient’s quality of life.